Not unlike the original iMac VESA adapter.
Thus, all you really need to do is fabricate a short adapter that will attach to the mount assembly internally, extend beyond the shell of the iMac, and attach to a VESA mount plate. The mount assembly is much the same as the old one with the major difference being the aforesaid orientation of the set screws. Important note: Macworld and I take absolutely no responsibility for any damage you do to your iMac during any step of any alteration or use of a homemade adapter. I’m merely pointing out possible paths to VESA compatibility for those willing to take a risk-an extremely slight one if you’re capable. Alternatively, the brains to let someone who really knows what they’re doing handle it. Now I’m going to address the distinct minority of the iMac community who have the ability and gumption to disassemble their iMac, as well as fabricate simple metal parts.
Advanced DIY (or have someone else do it)